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Common side effects are typically mild and transient: Pain, redness, or swelling at the injection site (most frequent) Mild diarrhoea or gastrointestinal upset Headache or dizziness shortly after administration Itching or mild skin reactions Temporary pink/red discolouration of urine These effects usually resolve within 2448 hours without intervention

356 For tumors deficient in apoptosis, such as those with SLFN11 inactivation or impaired p53-independent pathways, strategies to restore translational stalling (e.g., via tRNAse mimetics) or activate alternative stress responses may sensitize cells to DNA-damaging agents

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